• ECG, blood pressure, body temperature, and locomotor activity monitoring by telemetry in freely moving animals (Dogs, Monkeys, and Minipigs/Nanopigs)

• The animals are implanted with transmitters equipped with solid-tip ECG leads virtually eliminating muscle noise and movement artifact from the ECG signal

• All data evaluated by a board-certified veterinary cardiologist

• A colony of pre-implanted animals is available at all times for a quick start

• Respiratory rate, tidal volume, minute volume, and blood gas analysis

• Head-out plethysmography in rats

• Face mask connected to a pneumotach for dogs, monkeys and minipigs/nanopigs

• Hardware: Data Sciences International

• Software: Ponemah

Functional Observation Battery (FOB):

• Rats and mice

• Observations performed to cover 3 functional domains:

  • Behavioral

  • Autonomic

  • Neuromuscular (sensorimotor)

• About 30 parameters evaluated:

  • Observation of the animal in its home cage

  • Observation of the animal while being handled

  • Open field measurements

  • Evaluation of the animal’s reaction to various stimuli

Neurological Examinations:

• Dogs and monkeys

• About 15 to 20 tests performed:

  • Mental status

  • Gait and posture

  • Muscle tone

  • Spinal and facial nerve reflexes

• Renal function test in saline-loaded animals

• Urinalysis, including urine electrolyte measurements

Gastrointestinal transit in rats and mice