Small Molecules
The majority of drugs that are being developed are small molecules that are able to easily enter cells and can therefore act upon the function of the cells for particular therapeutic areas.
ITR Laboratories has the capability to perform all appropriate safety testing on small molecules, whether for IND or NDA submission to the FDA or OECD member countries. Since ITR's inception, we have been privileged to work with many drugs in development for a wide range of therapeutic areas.
Therapeutic areas include:
- Bone/Osteoporosis
- Cardiovascular
- Respiratory
- CNS
- Dermatology
- Diabetes
- Oncology
- Ophtalmology
- Infectious Disease
- Metabolic Disease
- Surgery
- Thrombosis
- Inflammation
- Many more...
Analytical method development and GLP validation by HPLC
Support general toxicology studies, genetic toxicology studies (bacterial reverse mutation, chromosome aberration and micronucleus) and hERG (the human Ether-à-go-go-Related Gene) Proteins
- Support inhalation toxicology studies; particle size distribution, analysis of inhalation mixtures for confirmation of aerosol homogeneity and concentration, and analysis of inhalation chamber atmospheres
- Our inhalation experts have extensive knowledge of aerosol science and can guide you and adapt to your needs
- HPLC & UHPLC with UV, PDA, fluorescence and light scattering detection
Preclinical and clinical LC-MS/MS sample analysis for the following matrices:
- Tissue Extracts
- Spinal Fluid
- Plasma
- Serum
- Urine
- Balf
- Cerebral
- Whole Blood
Methodologies are based on the 96-well format for protein precipitation, liquid-liquid extraction or solid phase extraction.
Equipment includes:
- AB Sciex Triple Quadrupole Systems
- 3x API 6500+
- 3x API 4000+
- Shimadzu Nexera (LC 40 Series)
Methodologies Based on 96-well Format:
- Protein Precipitation
- Liquid-Liquid Extraction
- Solid Phase Extraction