Biologics - ITR Laboratories Canada Inc.

In 2010 ITR Laboratory Canada established a Center of Excellence for the Development of Biologics to provide on site expertise and oversight of biopharmaceutical drug development programs. Some of the advantages conferred included:

All services are offered at a single site.
Both rodents and non-rodents species are tested in the same facility.
- Ensures consistency between protocols; common awareness of all information.
Excellent direct scientific oversight by senior staff.
Excellent face to face communication between departments.
No sample shipments.
- No risk of lost samples.
- Saves on time as samples can be accessed quickly for analysis.
- Saves on cost (no shipping costs).
Allows for an efficient and faster reporting timeline of the whole program.

Our team of experienced scientists conducts customized assays in compliance with ICH guidelines and current best practices to assure that your program is properly supported with the right data. Services offered include drug potency assays to support species selection and justification.

PROTEINS

ITR Laboratories Canada offers a full range of services to support the development of protein therapeutics

Tox species selection datasets: development and qualification of assays for drug potency, binding or signalling.
GLP Bioanalysis, usually by LBA, and pharmacokinetics to support regulatory filing.
GLP immunogenicity analysis: binding and neutralizing antibody assays.
PD biomarkers are a very useful adjunct to bioanalysis of proteins.

FACILITIES INCLUDE

Ligand binding lab:

Flow cytometer (BD FacsCanto II -2 lasers, 6 colors).
Multiple plate washers and readers (Both MolDev and Biotek).
All necessary support equipment.

Tissue culture room (BSL2, 2+):

Laminar flow hood, CO₂ incubators.
Microscopes with image capture systems.
All necessary support equipment (cell banking, etc..).

NUCLEIC ACIDS

ITR Laboratories Canada has years of experience with oligonucleotide therapeutics. We can assist with species selection, and suggest safety and PD biomarkers.

Tox species selection datasets: development and qualification of assays for drug potency, payload expression or target knockdown.
GLP Bioanalysis, by hybridization ELISA or QPCR.
Biomarker analysis for safety and pharmacodynamics.

FACILITIES INCLUDE:

Ligand binding lab:

Flow cytometer (BD FacsCanto II -2 lasers, 6 colors).
Multiple plate washers and readers (Both MolDev and Biotek).
All necessary support equipment.

Tissue culture room (BSL2, 2+):

Laminar flow hood, CO₂ incubators.
Microscopes with image capture systems.
All necessary support equipment (cell banking, etc.).

Molecular biology lab:

Tissue extraction (TissueLyzer, Polytron).
nucleic acid characterization (Agilent bioanalyzer) and quantitation (picogreen).

QPCR (Via7) and TaqmanLowDensityArrays

CELLS AND GENE THERAPIES

NEW AND EXCITING!
ITR Laboratories Canada announces its offerings for cell and gene therapeutics!

Our recently added services include:

Vivarium housing for immunocompromised rodents.
Test item administration by stereotactic injection.
Biodistribution and persistence assessment by QPCR and IHC.
Cell phenotype maturation by IHC or rtQPCR.
Payload expression or target knockdown by rtQPCR.

FACILITIES INCLUDE:

Ligand binding lab:

Flow cytometer (BD FacsCanto II -2 lasers, 6 colors).
Multiple plate washers and readers (Both MolDev and Biotek).
All necessary support equipment.

Tissue culture room (BSL2, 2+):

Laminar flow hood, CO₂ incubators.
Microscopes with image capture systems.
All necessary support equipment (cell banking, etc..).

Molecular biology lab:

Tissue extraction (TissueLyzer, Polytron).
nucleic acid characterization (Agilent bioanalyzer).
QPCR (Via7) and TLDA